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Among them, folic acid, or its active form, L-methylfolate, shows promise due to folates association with an elevated risk of depression, severe depressive symptoms, prolonged duration of depressive episodes, and increased likelihood of relapse [22,23]

Chen L, Chen X, Ruan B, Yang H, Yu Y

A systematic review and meta-analysis found no significant differences in all-cause mortality among these dosages, suggesting that doses greater than 3 g per day may not provide additional benefits [42]

Amino Acids , 2012, p

doi: 10.1016/j.cell.2013.12.010 [DOI] [PMC free article] [PubMed] [Google Scholar] 106.Zhang Y, Tan H, Daniels JD, et al