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81 Excessive A accumulation and deposition may trigger a complex downstream cascade that results in the symptoms of AD

Scientific Overview A modified 83-amino acid analog of IGF-1 with an extended half-life, studied for IGF-1 receptor binding kinetics, Akt/mTOR pathway interaction, and cellular proliferation signaling in preclinical research

doi: 10.1056/NEJMoa050434 73 ChenWHoffmannADLiuHLiuX

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Some of these factors include the cellular composition and vascular nature of the tissue(s) in question
