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This underscores why unexplained elevations, particularly above 1,000 pg/mL, should be taken seriously and investigated

Salehi PP, Kasle D, Torabi SJ, Michaelides E, Hildrew DM

Medication use Certain medications including proton pump inhibitors, metformin and birth control pills may lead to the side effect of vitamin B12 deficiency

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One example is the Jarisch-Herxheimer reaction, which may occur in those treated for syphilis or Lyme disease
