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Administration of an ionic liquid formulation of edaravone, combined with tetrabutylphosphonium cation, resulted in prolonged blood circulation time and reduced kidney distribution

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You start at 2.5 mg for the first month, then gradually increase every four weeks based on tolerance and results

We speculate that the main reason for not showing a significant difference is that the MEXAMETER used to measure the melanin index in this study cannot distinguish between the two types of melanin, eumelanin and pheomelanin, resulting in greater individual differences and variability