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While ergothioneine has been demonstrated to be protective in a number of other in vivo models of liver injury (46,66,95,96) , including the aforementioned model of diabetic liver damage (91)

Since background BMI can be largely different between races, caution is needed when interpreting and applying the results, including combination use with SGLT2is and finerenone

As for the downstream mechanism, due to the inhibition of NAD+/Sirt pathway, downregulation of Sirt1 causes decreased expression of FOXO, p53, PPAR , and Akt in the nucleus

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