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doi:10.1016/j.biopsych.2011.10.024
Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine
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Subsequently, clinical studies with pembrolizumab, another anti-PD-1 monoclonal antibody, in mCRPC patients also proved ineffective, indicating that monotherapy with PD-1 inhibitors in this patient population did not yield significant objective responses (Scheid et al., 2016)
