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313 Several therapeutic approaches targeting Met metabolism, including Met restriction, MAT2A inhibitors IDE397 and AG-270, are in clinical trials, and their therapeutic effects need to be verified

There is conflicting evidence regarding intestinal permeability changes during pregnancy and hypertension

Murine Studies Linking Oxidative Stress to SCD Clinical Severity Several published murine studies in the Townes SCD mouse model for drug development show the involvement of oxidative stress in the severity of the phenotype