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Description
So, diet can trump genetics
While GPX4 is central to protecting a variety of cells from ferroptosis, in lung adenocarcinoma cells, GPX4 deletion is not sufficient to induce ferroptosis 56
One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)
Consistent treatment helps maintain long-lasting brightness and improved clarity
Microbiology 145: 3465-3475
