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Muscarinic receptors at the auditory thalamocortical circuits and relevance to hearing

In diabetes, coronary circulation shows an accumulative level of acetylcholine (Ach), which causes contraction (Nitenberg et al., 1993)

As we age, the synthesis of glutathione decreases, leading to lower levels in the body

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Baseline reductions in structural connectivity also predict progression to poor cognitive outcomes at 3-year follow-up 141 and in PD patients with MCI they predict progression to dementia within 5 years 144 , with interhemispheric frontal and parietal connections being most implicated in cognitive impairment 141,144,145