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During sperm maturation, sperm transition proteins (TNP1 and TNP2) replaces the majority of the histone proteins of the spermatids, followed by the deposition of highly basic protamines (PRM1 and PRM2) in elongated spermatids and spermatozoa (Jambor et al., 2017)

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The addition of bevacizumab significantly improved PFS compared to endocrine treatment alone, however, there was no difference in OS between both groups

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