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Description
Kume O., Takahashi N., Wakisaka O
Bibcode:1996FEBSL.390..119O

Hydroxychloroquine (HCQ), a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and Sjgrens syndrome

Our in silico analysis suggested that both compounds occupy the same pocket at the STX7Munc13-4 interface but only ENDO12 is predicted to form a hydrogen bond (2.07 ) between its hydroxyl hydrogen and the side chain of S137 in the disordered region of STX7 that binds Munc13-4

b) The second finding comes from an extensive paper showing that bilirubin concentrations in the upper quartile of the RI and moderately elevated concentrations above the RI may be associated with the protective role of bilirubin against various diseases ( 32 )