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Other mechanisms may also be important in bortezomib induced peripheral neuropathy, including nuclear accumulations of ubiquinated proteins and altered protein transcription in sensory ganglion neurons 67, 68

The pharmacokinetic analysis revealed that S-Acetyl-L-glutathione is rapidly deacetylated to GSH post-administration before it can reach the bloodstream, resulting in the non-quantifiable levels of plasma SAG

For each sample, 120 L of plasma was aliquoted into two round-bottom 96-well plates, kept on dry ice, sealed with plastic film, and stored at 80 C until LC-MS/MS sample preparation and analysis

[DOI] [PubMed] [Google Scholar] 16.Klug A., Rhodes D

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