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Histamine acts as a neurotransmitter involved in the contractions of the intestinal muscles.[ref] People with food allergies and IBS had significantly higher levels of H1 and H2 receptors in their intestines.[ref] Histamine receptors in the brain: A 2026 study explored the role of histamine and histamine receptors in different regions of the brain

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The purpose of this state-of-the-art critical narrative review is to integrate disparate mechanistic, pre-clinical, and clinical data into a coherent conceptual model of phytochemical action in depression rather than to catalogue every published study

References Abdolrasulnia R, Wood JL (1980) Persulfide properties of thiocystine and related trisulfides

Inhibition of p38 MAP kinase as a therapeutic strategy