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Blood 137:11541165 Richardson PG, Beksa M, pika I, Mikhael J (2020) Isatuximab for the treatment of relapsed/refractory multiple myeloma

Furthermore, clinical manifestations of withdrawal, such as dysphoria and irritability, mirror neurobiological adaptive mechanisms that involve greater stress sensitivity and hyperactivation of the hypothalamic-pituitary-adrenal axis, which could account for the increase in BDNF levels [38, 39]
