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This process is believed to start with a depletion of GSH within the mitochondria, the "power plants" of cells
Dong et al., 2020)
[58] pyruvate, which is the only source of endogenous lactate in the brain, is at a crossroads of a number of metabolic pathways i.e
In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29
Endoscopy 2010;42(Suppl 2):E26
