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The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties

Undesirable symptoms of drug addiction include increased tolerance to intoxicating substances, continuing drug use despite unpleasant health, mental, and social consequences, and the appearance of withdrawal syndrome such as hand and muscle tremors, excessive sweating, irritability, hallucinations, depression, concentration deterioration, and anxiety

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At the end of the trial, blood samples were collected by cardiac puncture