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The study followed three women and two men over 18 months, including 12 months on a daily oral 2 mg dose of nitisinone, and six additional months without the drug

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Mitochondrial dysfunction Symptoms of ME/CFS such as PEM and fatigue less aided by rest have prompted the investigation of mitochondria and cellular energy metabolism since a deficiency here could contribute to these two key symptoms

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Novel Lp(a) lowering drugs such as Pelacarsen may avoid LA, which was investigated in a recently completed multicentre trial (NCT05305664)