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Nat Commun 11:498 Lee YZ, Yang CW, Chang HY et al (2014) Discovery of selective inhibitors of glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Alors que le glutathion standard peut tre partiellement dgrad par les enzymes digestives, la forme liposomale prserve ses proprits antioxydantes jusqu' son absorption

GHK exhibits high affinity for copper and can spontaneously bind with it to form the chelate complex GHK-Cu (Dou et al., 2020)

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists