glutathione conjugation wiki S-transferase A1 File:Paracetamol metabolism.png - Wikimedia Commons
Description
All of these factors can contribute to low glutathione levels and may help explain why older people are more susceptible to age-related conditions

Two major types of EVs, microvesicles, and exosomes contain a variety of components (e.g., enzymes, miRNAs, transcription factors, membrane-bound and soluble receptors, lipids, and DNA, etc.) and involve in cell communication, migration, angiogenesis, and tumor cell growth
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

Tissue repair effects appear to take a few weeks, with individual responses varying
Since B12 shots contain much more B12 than the body can readily use or store, there is a lot of waste