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Melatonin has been implicated in the epigenomic regulation of hypertension by decreasing the mRNA expression levels of agt1, ace, and agtr1 which promoted vasodilation and alleviating hypertension (Tain et al., 2017)

More recently, spinocerebellar ataxia type 2 has also been linked to the presence of a transition polymorphism in the GSTO2 gene (rs2297235 A183G) which significantly correlates with the age at disease onset

J., Downie A

Marrogi AJ, Travis WD, Welsh JA, Khan MA, Rahim H, Tazelaar H, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Mardikian P.N., LaRowe S.D., Hedden S., Kalivas P.W., Malcolm R.J