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A highly significant non-synonymous SNP was found at position 15,656,689 ( p -value = 5.61 10 8 ) in an ankyrin repeat protein (Medtr2g438720), and the surrounding region contained multiple ankyrin repeat genes within 1 kb of many top SNPs (Figure 4A and Table 2)

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Also, patients should be warned about the danger of taking folic acid in place of vitamin B 12, because the former may prevent anemia but allow progression of subacute combined degeneration

doi: 10.1016/j.earlhumdev.2020.105190 22

Most users notice appetite changes first, then gradual weight changes over weeks to months, especially when dose increases are done slowly and side effects are managed