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Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

10.1515/9783110527872-009 16 De FranceschiL.BertoldiM.MatteA.Santos FrancoS.PantaleoA.FerruE.et al (2013)

This condition may depend on the type 2 polarization, diminishing type 1 immunity devoted to fighting infections, ICAM-1 overexpression on epithelial cells (ICAM-1 is the primary receptor for rhinoviruses), and chronic inflammation that promotes microbial rooting [89]

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