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The Trendelendburg position keeps a left-ventricular air bubble away from the coronary artery ostia (which are near the aortic valve) so that air bubbles do not enter and cause a myocardial infarction by blocking the coronary arteries

Additionally, accumulation of cyanocobalamin metabolites may occur in severe renal impairment, though this is rarely clinically significant

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2.2.1 Association between increased Hcy levels and MetS While the precise mechanism underlying how HHcy contributes to MetS remains incompletely understood, substantial evidence supports HHcy as a major risk factor for MetS development