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A randomized, double-blind, placebo-controlled trial was carried out to evaluate whether ALA supplementation can improve lymphocyte function in HIV-infected subjects with a history of failure to respond to highly active antiretroviral treatment [120]

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Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration

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H., Pabst, M