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doi: 10.1159/000327821, 57

Current research suggests: In summary, berberine is generally safe for kidney health when used responsibly, but long-term data is still limited

It is considered a marker for neuroinflammation because of its relationship to glial activation and BBB permeability ( Creatine is a critical regulator of energy homeostasis in the brain [e.g., (83)]

6.1.3 Iron chelators Deferiprone (DFP), an FDA-approved oral iron chelator capable of crossing the bloodbrain barrier, reduces nigral iron content, suppresses -syn aggregation, and protects DA neurons through dual inhibition of iron-dependent -syn fibrillation and ferroptosis

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