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Furthermore, this complex potentially serves as an activation site for calmodulin (23)

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Over time, that burden can contribute to what scientists call oxidative stress, a process that occurs when the production of free radicals outpaces the body's ability to neutralize them

The activation of Oma1 leads to mitochondrial fragmentation and induces an integrated stress response along the Oma1-Dele1-Atf4 signaling axis, which can inhibit ferroptosis and provide protective effects [166]

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