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Dysbiosis and increased intestinal permeability (leaky gut) may amplify neuroinflammatory state of the brain, further justifying the need for research into interventions combining metabolic and microbiota-based therapies

Doxorubicin toxicity was evaluated by macroscopic and microscopic examination of the heart and other organs by biochemical analyses
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JBTR was supported by CNPq, CAPES, FAPERGS, FINEP and INCT/CNPq Neuroprotection (INCT-NeurPro) (408446/2024-2)

10.1016/j.cmet.2013.08.019 41
