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International journal of molecular sciences , 26 (6), 2691

Women with a history of blood clots, heart disease, stroke, certain cancers, liver disease, uncontrolled hypertension, porphyria or migraines with neurological symptoms may be advised against using it

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This study, over an 8 month period, evaluated 300 individuals between 65 and 96 years of age

However, other circumstances can also be responsible, such as viral pneumonia, sepsis, chest injuries, burns, blood transfusions, aspiration of gastric contents, pancreatitis, intravenous drug use, abdominal trauma, and acute radiation syndrome [165,166,167]