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Cholesterol homeostasis is a complex dynamic equilibrium process composed of regulated pathways of biosynthesis, uptake, efflux and esterification, and it involves a complex web of enzymes, transport proteins, membrane-bound transcription factors and epigenetic modifications

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

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