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A post-hoc analysis of the CARES clinical trial was recently published, showing a reduction of CKD progression (a drop in GFR of 0.5 ml/min/year) in patients with gout treated with allopurinol or febuxostat who maintained a UA level of less than 6 mg/dL for a median of 2.5 years.50 These data could suggest that the deposits of monosodium urate crystals in the kidneys may be responsible for the progression of kidney disease

(Source 1) Glutathione plays a critical role in every cell in the body
Thus, interfering with cAMP signaling may provide promising approaches to counteract the cognitive effects of SD (Vecsey et al., 2009)

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