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Wu S, Yuan X, Tang Z, Zang K, Wang C, Li Z, Li H, Ye X, Dang Y (2024) Fast freezing inhibits melanin synthesis of melanocytes by modulating the Wnt/-catenin signalling pathway

The review supports the biological plausibility of prenatal folate altering epigenetic programming, but it does not prove that prenatal folate causes clinical undermethylation

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2, while the 44 studies of the last 5 years are summarized in more detail in Table 1