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Thompson, D.A., et al

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Researchers should confirm that batch documentation includes peptide identity, theoretical and observed molecular weight or mass confirmation, chromatographic purity, lot number, analytical date, storage recommendation, analytical method or method summary where available, and batch-specific quality documentation

Thereby, individual differences in metabolic or proteolytic activity, differences in splenic function, or variation in expression of (compensating) PK isoenzymes and the activity of other compensating pathways may contribute to the disease phenotype, as well as epigenetic factors and co-inheritance of other (red cell) diseases (Bianchi and Fermo, 2020)