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It was against this background that Jerne developed his model of 'natural selection theory'

Leaky gut may also stem from systemic inflammation, where cytokines like interleukin (IL)1, IL-6, tumor necrosis factor (TNF)-, and interferon (IFN)- disrupt gut permeability and promote bacterial translocation by weakening tight junctions [21]

Next, the covalent proteinligand adduct system was prepared using the AMBER22 suite of programs 43,45

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