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[1] Gamma-butyrobetaine is then hydroxylated by gamma butyrobetaine hydroxylase (a zinc binding enzyme [10] ) into l-carnitine, requiring iron in the form of Fe 2+

Sex-specifically genetically predicted l-carnitine was related to higher triglycerides in men and women (Fig

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Signaling Pathways Affected by L-Carnitine Extensive research has focused on elucidating the signaling pathways associated with L-Carnitine, highlighting the involvement of Sirtuin 3 (SIRT3) [72] and nuclear factor erythroid 2-related factor 2 (Nrf2) [73]

They play critical roles in the metabolism of fatty acids, facilitating energy production at the cellular level