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In groups four, five and six TRIS-BPC157 was applied intramuscularly (i.m.) either at the 7 th , 9 th , 14 th and 16 th post-operative day (10 g/kg b.w.) or once daily in the period of the 7 th -21 st post-operative days (10 g or 10 ng/kg b.w.)

Investigations into the effects of microplastics on the neuroendocrine system via the gut-brain axis revealed that exposure to 50 m MPs significantly reduced colonic mucin production and induced substantial alterations in the gut microbiota, in the 50 m - 100 g/L exposure group, a marked decrease in oxytocin (OT) content in the medial prefrontal cortex was observed, along with damage to the bloodbrain barrier, these findings highlight the potential adverse effects of environmental microplastic exposure on the neuroendocrine framework in social mammals, including humans (27)

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