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Add water slowly down the inside wall of the vial to promote complete dissolution without excessive foaming

Shortening the time from the onset of ALS symptoms to diagnosis is essential to evaluate and initiate treatments and therapeutics sooner, especially if they exert a meaningful disease-modifying effect

doi:10.1038/s41586-019-1730-1 6

[DOI] [PMC free article] [PubMed] [Google Scholar] 135.Collins FL, Irwin R, Bierhalter H, Schepper J, Britton RA, Parameswaran N, McCabe LR
R -ALA was obtained after deprotection, NaBH 4 reduction, mesylation, and hydrolysis R -ALA was achieved
