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PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG

The oxidation of compound with t-BuOOH produces the transient selenoxide , which undergoes a spontaneous cyclization to produce the dioxyselenurane isolated compound structure was confirmed by spectroscopic methods and single X-ray crystallography

This was done independently of the Clowes Fund

At the indicated time points, Cell lysates were analyzed by western blotting using anti-GPX4 antibody
