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[45] Collectively, the prolonged ROS sustain the harmful effects of hyperglycemia by epigenetic causes, chronic oxidative damage, and proinflammatory effects independent of the actual glucose level, contributing to the onset of diabetes
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Genetics of ABCB1 in cancer

In contrast, while full-length pVHL and the p19 variant interact with HIF-1, the association was abrogated by further N-terminal and C-terminal truncations
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