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Beyond oxidative injury, these exposures act synergistically on endocrine regulation of male fertility

To illustrate, radiotherapy results in mitochondrial damage and mitophagy, which releases free fatty acids and increases lipid peroxidation, thereby inducing ferroptosis in tumor cells [137]

Challenges in the Diagnosis of Magnesium Status Nutrients (2018), DOI: 10.3390/nu10091202 3

As a key antioxidant, glutathione helps protect cells from oxidative stress and the associated damage caused by free radicals

ALOX15 KD did, however, lead to decreased extracellular GSSG ( P = 0.021), with marginal but insignificant increases in extracellular GSH:GSSG ( P = 0.083)