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doi: 10.1080/15548627.2020.1731266 69 MeyerNHenkelLLinderBZielkeSTascherGTrautmannSet al
[298], transcriptomics was employed to study OS in neuroinflammation, revealing the expression of genes involved in coagulation and GHS-related pathways involving microglia and macrophage-infiltration, highlighting the usefulness of the technique [298]
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On the other hand, pyridoxine is the coenzyme of dopa decarboxylase, converting L-DOPA to dopamine 49 , which raises a concern that pyridoxine supplementation may result in peripheral metabolism of L-DOPA and a lack of bioavailability in the brain 58
GLO1 inhibition would represent a novel mechanism of action among psychiatric drugs
