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5hmC is the main modification status for a many CpGs situated at transcriptionally active regions, such as DNaseI-hypersensitive regions and enhancers [35], suggesting its positive correlation with gene expression [41]

The amplification of MUC1 gene led to over-expression of the MUC1 C-terminal subunit (MUC1-C) complex, which could mediate the TNBC cell self-renewal ability and tumor origin [373]

2008), metabolites, and nucleic acids (Ruf and Mueller 2006), enables more precise disease detection and monitoring, overcoming the limitations of traditional biomarkers found in blood and other body fluids

Aging Cell 19 , e13059 (2020)

Other meta-analyses of observational studies have reported inverse associations between serum selenium concentrations and breast cancer (72) and thyroid cancer (73)