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8 Among nonradical ROS, H 2 O 2 is produced mainly by NADPH oxidases (NOX) and other enzymes and functions as a two-electron oxidant in redox signaling, with selective reactivity toward certain protein cysteines
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Nuclear Localized Pyruvate Dehydrogenase Complex (nPDHc) The primary enzyme in the nucleus that is responsible for the generation of acetyl-CoA is ATP-citrate lyase, ACLY
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