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45,78,84 Leptin can also directly stimulate inflammation by promoting the M1 macrophage phenotype 120 and increasing pro-inflammatory cytokines such as IL-6, IL-1, and TNF-

Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Seino Y, Fukushima M, Yabe D

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& Koutras, D
