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(i) Group:1 include normoxia (N) considered as control that received only vehicle (ii) Group 2 : Hypoxia (H) received only vehicle and was exposed to hypoxia for 12 h (iii) Group 3: Normoxia + Quercetin (NQ) was supplemented with quercetin (50 mg/Kg BW) without hypoxia exposure (iv) Group 4: Hypoxia + Quercetin (HQ) received quercetin (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h (v) Group 5: Normoxia + Acetazolamide (NA) was supplemented with acetazolamide (50 mg/Kg BW) without hypoxia exposure (vi) Group 6 : Hypoxia + Acetazolamide (HA) received acetazolamide (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h

Colchicine has been used to treat gout for many years, but its high toxicity at anti-tumor doses, possibly because of its quasi-irreversible binding tubulin, has limited its anticancer therapy development

Brand name versus compounded formulations Understanding the difference between brand-name and compounded versions is essential for interpreting dosage charts correctly