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The role of several enzymatic (glutathione reductase, ascorbate peroxidase superoxide dismutase, and catalase) and non-enzymatic (phosphorus, phytochelatins, proline, glutathione, salicylic acid, and nitric oxide) substances under As (V/III) stress have been explained using a theoretical framework that illustrates the toxicity and translocation pathways of this metalloid in plants
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Therefore, presenilin mutations may promote neurodegeneration by derepressing ferroptosis, which has implications for disease-modifying therapeutics.
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