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However, tumor-associated blood vessels are dysfunctional and leaky (93), and the continuous exposure of BECs to pro-angiogenic factors can lead to endothelial anergy, a state in which ECs stop responding to inflammatory signals (90)

The administration of H 2 to mice, rats, and racehorses subjected to acute or chronic exercise stress was found to exert anti-fatigue effects (4649)

The change of H 2 S concentration is related to a variety of endocrine disorders, and the change of hormone concentration also affects the synthesis of H 2 S

Four differently expressed metabolites are identified

Long term followup and patterns of failure in patients with acute myeloid leukemia and high risk myelodysplastic syndrome treated on studies combining a hypomethylating agent and the histone deacetylase inhibitor valproic acid