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Let's establish one thing at the beginning

[5] When the reaction proceeds from pyruvate to lactate, the first step is the binding of NADH, the reducing agent, to the enzyme, which is followed by conformational changes that facilitate the formation of hydrogen bonds between specific residues surrounding the active site and the carbonyl carbon of pyruvate, namely C2, and the subsequent interaction between NADH and pyruvate

In these models sulfanegen is effective in reversal of cyanide toxicity by IM injection and therefore should meet the three minute solution

[DOI] [PMC free article] [PubMed] [Google Scholar] Duffau POzanne ABonnet FLazaro ECazanave CBlanco PRivire EDesclaux AHyernard CGensous N, et al