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A strong evidence of HGF-MET axis importance in the human development of nervous system comes from some studies that reveal a genetic implication of HGF and MET genes in some NDDs such as autism spectrum disorder (ASD), schizophrenia, and non-syndromic hearing loss

EMT is observed in the process of renal interstitial, pulmonary and liver fibrosis [56,57,58,59], as well as in specific ocular tissue [32]

However, the condition is often stressful, and people may undergo serious depression in some of the worst cases

Several developments on the horizon could shape how this combination is studied and potentially applied

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