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Liu, T., Liu, Y., Zhao, X., Zhang, L., Wang, W., Bai, D., Liao, Y., Wang, Z., Wang, M., & Zhang, J
doi: 10.1073/pnas.1017213108 126 Ushio-FukaiMAlexanderRW
Ubiquitin-dependent lysosomal degradation of GPCRs and long-term desensitization GPCR ubiquitination, as shown initially for the 2 AR and the chemokine receptor CXCR4, is a critical tag that directs internalized receptors to lysosomes, although initial agonist-induced endocytosis of these receptors does not require receptor ubiquitination [70, 77]
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