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By definition, HIT is a pathological imbalance between histamine intake and the bodys capacity to metabolize or break it down in the intestines, thereby leading to its accumulation and activation of histamine receptors across multiple organ systems

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This conversion is demanding, and can be compromised in a range of conditions

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Hypothyroidism may induce an inflammatory response in the adrenal gland, which may result in the infiltration of inflammatory cells (Kooistra et al

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